Faculty

Ariella Shikanov
Biomedical Engineering

In our research we aim to create artificial constructs that direct tissue regeneration and restore biological function employing methods from engineering, materials, chemistry and life sciences. To achieve this, we use natural hydrogels and multifunctional synthetic hydrophilic polymers. Three main application realms of our research are reproductive biology, toxicology and cancer.

Katharine Francesca Barald
Biomedical Engineering

We are interested in the early development of neuronal lineages from the embryonic neural crest; which appears transiently during development and which is a source of peripheral nervous system neurons, among many other cell types. We use specific monoclonal antibodies and no-flow cytometry to isolate neural crest subpopulations. We also study the role of the neurofibromatosis I gene (a tumor suppressor gene) in neural crest development and neuronal/ melanocyte/Schwann cell lineage specification and apoptosis, using mouse embryonic stem cells. An additional line of research examines the role of the embryonic hindbrain, periotic mesenchyme and neural crest in shaping inner ear development and the roles of transcription factor and growth factor genes (e.g. BMPs) and their antagonists, such as Noggin, Chordin and DAN, in axis formation and development of the embryonic otocyst.

Julie Biteen
Chemistry

Joseph L. Bull
Biomedical Engineering

Our research is focused in the areas of Gas Embolotherapy, Vascular Mechanics,Total Artificial Lungs,Liquid Ventilation, and Biological Microfluidics. Biotransport relates to the transport of energy, mass, and momentum essential to the function of living systems. Transport processes are evident from the smallest spatial scales of molecular dimensions to the large scales of whole organs and of organisms themselves.

David T. Burke
Human Genetics

The Burke Laboratory research effort is concentrated in three main areas: (1) the analysis of the stability of gene expression during mammalian aging, (2) quantitative trait locus (QTL) analysis of complex, mulitgenic traits in the laboratory mouse, and (3) the development of engineering systems for microfluidic analysis.

Mark A. Burns
Chemical Engineering

We are a research group focusing in the advancement and proliferation of microfluidic technology by developing baseline technology and creating new and exciting applications using microfluidics. This includes biochemical separations, field-enhanced separations, microfabricated chemical analysis systems, DNA genotyping and sequencing.

Lisa Larkin
Molecular & Integrative Physiology

Our research focuses on creation of engineered musculoskeletal tissue with functional myotendinous (MTJ) and neuromuscular (NMJ) junctions.

Nikolaos Chronis
Biomedical Engineering

Bio-MEMS and Microfluidics, Biomedical Optics, Neural Engineering.

Lola Eniola-Adefeso
Chemical Engineering

Our research goal is to use knowledge of the cellular inflammatory response and blood flow dynamics to design bio-functionalized particles for targeted drug delivery and imaging. Due to their high specific interaction with their counter-receptors and their carefully regulated expression (limit to inflammation), leukocyte-endothelium adhesion molecules (LECAM) are attractive molecules for vascular targeting in human diseases in which inflammation plays a role.

Xudong (Sherman) Fan
Biomedical Engineering

Jianping Fu
Mechanical Engineering and Biomedical Engineering

Our group's interests lie at the nexus of micro/nanoengineering, biophysics, biology, and biotechnology. In the coming years, we will focus on developing integrated systems for high throughput quantitative micro/nanoscale analysis of molecular and cellular functions. More specifically, we will develop integrated techniques to investigate biomolecules confined in micro/nanofluidic environments.

William V. Giannobile
Biomedical Engineering

Bio-Nanotechnology, Biomaterials, Biomedical Imaging, Tissue Engineering and Regenerative Medicine.

James B. Grotberg
Biomedical Engineering

Our laboratory engage in a variety of scientific endeavors which have, as a common base, the underlying principles of fluid mechanics and transport processes. Our work involves investigations of the respiratory, cardiovascular, and ocular systems using both experimental (benchtop & animal) and theoretical (analytical & computational) approaches.

Erdogan Gulari
Chemical Engineering

Our group’s research is on reactions at interfaces and developing microfluidic MEMS devices for biosynthesis and genetic diagnosis. Currently the largest effort in my group is devoted towards making “biochips” or DNA and peptide chips for gene expression, SNP detection and drug – protein interactions. We are into our third generation DNA chips and microfluidic reactor systems. Our patented technology allows massively parallel synthesis of DNA oligomers and peptides on silicon/glass and plastic chips. In terms of application we are focusing on diagnostic applications in the area of water and food safety as well as medical diagnostics.

L. Jay Guo
Electrical Engineering and Computer Science

Nanoelectronic devices, nanofabrication technology and its application in optical and magnetic devices.

John Hart
Mechanical Engineering

Research in the Mechanosynthesis Group focuses on synthesis, properties, and applications of nanostructures and nanomaterials. Our work encompasses fundamental studies of synthesis and structure, development of novel material and device applications, and creation of machines and processes for scalable and precise nanomanufacturing.

Robert T. Kennedy
Chemistry and Pharmacology

Microfabricated analytical systems combining high speed capillary electrophoresis with zeptomole detection limits for on-line monitoring of cellular signaling events in insulin release or neurotransmission.

Katsuo Kurabayashi
Mechanical Engineering

Microelectromechanical systems (MEMS); microscale thermal engineering and design; heat transfer in micro/nano structures; semiconductor processing for micromechanical structure fabrication; microfluidic device; sensors and actuators.

Joerg Lahann
Chemical Engineering

Surface engineering, advanced polymers, biomimetic materials, engineered microenvironments, and nano-scale self-assembly.

Ronald G. Larson
Chemical Engineering

Our Research focuses on Rheology of Complex Fluids. Through rheological experiments, theory, and computer simulations, I am trying to work out the relationship between the structure of complex fluids and their rheology. Such knowledge is valuable in the optimal design of such fluids for applications in the polymer, pharmaceutical, and electronics industries. Of particular interest at present are branched polymer melts, surfactant solutions, and biopolymers.

Jennifer J. Linderman
Chemical Engineering

Our research centers on the application of chemical engineering principles to the study of fundamental problems in biology and medicine. In particular, we focus on the biochemical and biophysical mechanisms a cell uses to sense, respond to, and interact with its environment. This communication between cells and their surroundings is critical not only to normal mammalian cell function but also to the detection of foreign invaders (immunology) and the response to drugs (pharmacology). An ability to quantitatively understand and manipulate these mechanisms is thus crucial to many areas of modern biotechnology.

Allen Liu
Mechanical Engineering and Biomedical Engineering

Gary D. Luker
Microbiology and Immunology

Microbiology and Immunology faculty conduct research in the areas of microbial pathogenesis. These include those interested in viral pathogens including DNA and RNA viruses that cause acute and persistent infections of humans and model organisms.

Michael Mayer
Chemical Engineering

Research in the Biomembrane Lab focuses on transport and signaling processes across biological membranes. The goal of the group is to increase the molecular understanding of these processes and ultimately to employ the ensuing insight to diagnose and possibly treat human disease. We are particularly interested in ion channel proteins that are involved in Alzheimer’s disease and in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and type I diabetes mellitus, as well as transporter proteins that are responsible for resistance to chemotherapy in treatment of cancer.

Jens-Christian D. Meiners
Biophysics

Our lab has been studying Lac repressor-mediated DNA looping as a model system for understanding biomechanical gene regulation. Our thinking about gene regulation is dominated by biochemistry, yet the DNA containing our genes is a polymeric molecule whose mechanical properties need to be carefully considered. For certain regulatory processes such as DNA looping, that require contortions of the DNA, the mechanics might actively participate in controlling expression.

Mark E. Meyerhoff
Chemistry

Our research interests are in the areas of bioanalytical chemistry, electrochemical and optical sensors, novel nitric oxide releasing/generating biomaterials, and immunoassays.

Sunitha Nagrath
Chemical Engineering and Biomedical Engineering

Leslie Satin
Pharmacology

Our rresearch is concerned with two broad areas: 1) The role of ion channels and membrane excitability in the control of insulin exocytosis from pancreatic islets of Langerhans in health and disease, and 2) the cellular and molecular mechanisms which lead to synaptic dysfunction following traumatic brain injury (TBI). Techniques used in our research include patch clamp electrophysiology, intracellular free [Ca2+] measurements, PCR and RT-PCR, western blotting, FRET, immunocytochemistry, mathematical modeling, cell culture, confocal microscopy, gene transfection (including using adenovirus approaches) and secretion measurements.

David H. Sherman
Chemistry and Pharmacology

Our research is particularly interested in the biosynthesis of terrestrial and marine natural products. A large number of novel natural products are being discovered from terrestrial and novel marine microbes. These exciting sources of new chemical entities will provide a wealth of unique information about the organization, structure, and regulation of genes involved in secondary metabolism. The focus over the past five decades has been entirely on secondary metabolite pathways of terrestrial microorganisms.

Michael J. Solomon
Chemical Engineering

Our research interests are in the area of complex fluids – soft materials with properties intermediate between fluids and solids. His group has applied new 3D confocal microscopy methods to generate discoveries in nanocolloidal assembly, colloidal gelation, and the biomechanics of bacterial biofilms.  His work has also included discovery of a universal scaling for polymer scission in turbulence that identifies the limits that scission imposes on turbulent drag reduction.  Other research interests have included the rheology of polymer nanocomposites, the microrheology of complex fluids and the microfluidic synthesis of anisotropic particles.

Jan Philip Stegemann
Biomedical Engineering

Our laboratory focuses on how cells interact with the 3D protein matrix around them, and how these interactions can be used to develop better biomaterials and engineered tissues. The biologically-derived proteins collagen and fibrin are of particular interest, due to their role as structural proteins in tissues and the range of effects that these polymers can have on cell function. We are developing composite biomaterials that combine the structural and biochemical features of these polymers, and which also incorporate other proteins that direct cell function.

Shuichi Takayama
Biomedical Engineering

Our research interests specialize in the development of microfluidics and micro/nanotechnology platforms capable of testing cells and subcellular components with combinations of mechanical, chemical, electrical, topographical, and thermal stimuli. We apply combinations of these factors to create physiologically relevant in vitro environments that allow us to better understand cell behavior and function in healthy and diseased states in vivo.

Nils G. Walter
Chemistry

Non-coding ribonucleic acid (RNA) has recently been found to be the key component, often capable of enzymatic action, in a multitude of essential cellular processes, such as gene regulation - through processes including RNA interference and riboswitching, translation, and splicing. RNA thus is increasingly finding important applications in modern biotechnology and medicine, for example as biosensor and gene therapeutic agent. Our research explores the world of such catalytic RNAs, or "ribozymes", as well as other non-protein coding RNAs by using single-molecule and bulk-solution biochemical and biophysical tools. Which means that we work on fascinating biological catalysts at the interface of Chemistry, Biology, and Physics.

Euisik Yoon
Electrical Engineering and Computer Science

Our research is particularly interested in BioMEMS, Microfluidics, Biosensors, and Integrated Microsystems.

Edward T. Zellers
Chemistry

Our research is highly interdisciplinary, involving collaborations with faculty and students from several other departments on campus, as well as researchers at national laboratories and private research and development firms. Our current research involves: development of chemical microsensors and microsensor arrays for monitoring volatile and semi-volatile organic molecules in air and biological media development of microfabricated preconcentration and separation devices and strategies for complex mixtures of such molecules integration of these and related devices in microanalytical systems for complex mixture analysis design, synthesis, and characterization of new materials for use in such microsystems implementation of microsystems in monitoring applications related to environmental health (e.g., personal inhalation exposures, local or global air-quality monitoring networks, homeland security monitoring, determinations of breath biomarkers of disease).